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I will say that there are medications which can help slow the progression of the disease when used as a first line when you are diagnosed. my husband is taking both azilect, an mao-b inhibitor and, after bed side effects from mirapex and selegiline, added dynacirc cr (a calcium channel blocker which is off label but since he is also a cardiac patient was acceptable to his doctor.)
 
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Dopamine antagonists are primarily used as anti-psychotics. they bind but don't stimulate dopamine receptors - they copy the effect of da.
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Co-careldopa as you know is the uk equivalent of sinemet. the cr from is a controlled release which means that he is probably taking a coated tablet which allows for a somewhat steady or incremental release of the levodopa and the carbidopa (which runs interference for the l-dopa).
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